Title : NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production.

Pub. Date : 2020 Apr

PMID : 31829469






2 Functional Relationships(s)
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1 Pretreatment of HL-7702 cells with OPN promotes hyperactivation of JNK and subsequent decrease of tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), resulting in impaired insulin signaling, which can be reversed by inhibiting ER stress. Tyrosine insulin receptor substrate 1 Mus musculus
2 Pretreatment of HL-7702 cells with OPN promotes hyperactivation of JNK and subsequent decrease of tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), resulting in impaired insulin signaling, which can be reversed by inhibiting ER stress. Tyrosine insulin receptor substrate 1 Mus musculus