Title : Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy.

Pub. Date : 2020 Jan

PMID : 31759089






3 Functional Relationships(s)
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1 Further investigation found that GPS enhanced the stabilization of IkappaBalpha by promoting the interaction of beta-arrestin2 with IkappaBalpha via TGR5 activation, which contributed to the inhibition of NF-kappaB signalling pathway. gentiopicroside arrestin, beta 2 Mus musculus
2 Moreover, GPS increased the TGR5 protein levels and promoted the interaction between IkappaBalpha and beta-arrestin2, thereby inhibiting the reduction of IkappaBalpha and blocked NF-kappaB p65 nuclear translocation in the kidneys of STZ-induced diabetic mice. gentiopicroside arrestin, beta 2 Mus musculus
3 Collectively, these data suggested that GPS regulates the TGR5-beta-arrestin2-NF-kappaB signalling pathway to prevent inflammation in the kidneys of diabetic mice, and ultimately ameliorates the pathological progression of diabetic renal fibrosis. gentiopicroside arrestin, beta 2 Mus musculus