Title : TAZ Is a Negative Regulator of PPARĪ³ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance.

Pub. Date : 2020 Jan 7

PMID : 31708444






3 Functional Relationships(s)
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1 In vitro and in vivo mechanistic studies revealed that the TAZ-PPARgamma interaction is partially dependent on ERK-mediated Ser112 PPARgamma phosphorylation. seryl-seryl-seryl-arginine peroxisome proliferator activated receptor gamma Mus musculus
2 In vitro and in vivo mechanistic studies revealed that the TAZ-PPARgamma interaction is partially dependent on ERK-mediated Ser112 PPARgamma phosphorylation. seryl-seryl-seryl-arginine peroxisome proliferator activated receptor gamma Mus musculus
3 As adipocyte PPARgamma Ser112 phosphorylation is increased in obesity, repression of PPARgamma activity by TAZ could contribute to insulin resistance. seryl-seryl-seryl-arginine peroxisome proliferator activated receptor gamma Mus musculus