Title : NLRP3 inflammasome mediate palmitate-induced endothelial dysfunction.

Pub. Date : 2019 Dec 15

PMID : 31705915






1 Functional Relationships(s)
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1 Using siRNA and Lenti-Virus to inhibit NLRP3 abolished palmitate-induced IL-1beta release and restored impaired phosphorylation of IRS-1 (Tyr), Akt (Ser473) and eNOS (Ser1177) and ACh-mediated endothelium-dependent vasorelaxation induced by palmitate. Tyrosine insulin receptor substrate 1 Mus musculus