Pub. Date : 2019 Oct 29
PMID : 31665640
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 2 | Here, we show that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 3 | Here, we show that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 4 | Here, we show that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 5 | GLUL-deficient PDAC cells are capable of the TCA cycle but defective in aKG-coupled glutamine biosynthesis and subsequent nitrogen anabolic processes. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |
| 6 | Therefore, GLUL-mediated glutamine biosynthesis couples the TCA cycle with nitrogen anabolism and plays a critical role in PDAC. | Glutamine | glutamate-ammonia ligase (glutamine synthetase) | Mus musculus |