Title : HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells.

Pub. Date : 2019 Dec 1

PMID : 31661640






1 Functional Relationships(s)
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1 Stimulation of telomerase activity in the HMGB2-deficient cells may be related to activation of the PI3K/protein kinase B/ glycogen synthase kinase-3beta/beta-catenin signaling pathways by HMGB1, augmented TERT/telomerase RNA subunit transcription, and possibly also because of changes in telomeric repeat-containing RNA (TERRA) and TERRA-polyA+ transcription. poly If high mobility group box 2 Homo sapiens