Title : Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin.

Pub. Date : 2019 Nov 29

PMID : 31653698






4 Functional Relationships(s)
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1 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine catenin beta 1 Homo sapiens
2 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine catenin beta 1 Homo sapiens
3 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine catenin beta 1 Homo sapiens
4 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine catenin beta 1 Homo sapiens