Title : Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains.

Pub. Date : 2020 Jan

PMID : 31558800






1 Functional Relationships(s)
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1 Cells expressing TTYH3-BRAF exhibited increased MEK/ERK signaling, which was blocked by clinically achievable concentrations of sorafenib, trametinib, and the paradox breaker PLX8394. 5-(1H-pyrrolo(2,3-b)pyridin-3-ylmethyl)-N-((4-(trifluoromethyl)phenyl)methyl)pyridin-2-amine B-Raf proto-oncogene, serine/threonine kinase Homo sapiens