Title : Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice.

Pub. Date : 2020 Mar

PMID : 31527829






2 Functional Relationships(s)
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1 In WT mice, PGE2 increased chloride reabsorption via EP1 in isolated perfused thick ascending limb (TAL), but PGE2 or EP1 deletion did not affect vasopressin-mediated chloride reabsorption. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 Overall, EP1 mediated TAL and IMCD transport in response to PGE2 is unaltered in Htn, and EP1 is protective in HKD. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus