Title : Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling.

Pub. Date : 2020 Jan

PMID : 31506605






2 Functional Relationships(s)
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1 Preclinical studies using multiple in vitro nAR-negative BCa cell lines and an in vivo mouse model all demonstrated that targeting this newly identified DHT/mAR-SLC39A9/Galphai/MAPK/MMP9 signaling with small molecules mAR-SLC39A9-shRNA or Galphai-shRNA, and not the classic antiandrogens including enzalutamide, bicalutamide, or hydroxyflutamide, could suppress nAR-negative BCa cell invasion. nar solute carrier family 39 (zinc transporter), member 9 Mus musculus
2 Preclinical studies using multiple in vitro nAR-negative BCa cell lines and an in vivo mouse model all demonstrated that targeting this newly identified DHT/mAR-SLC39A9/Galphai/MAPK/MMP9 signaling with small molecules mAR-SLC39A9-shRNA or Galphai-shRNA, and not the classic antiandrogens including enzalutamide, bicalutamide, or hydroxyflutamide, could suppress nAR-negative BCa cell invasion. nar solute carrier family 39 (zinc transporter), member 9 Mus musculus