Title : Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2-nAChR-p300-ACE pathway.

Pub. Date : 2019 Nov

PMID : 31500447






4 Functional Relationships(s)
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1 Nicotine exposure during pregnancy programs osteopenia in male offspring rats via alpha4beta2-nAChR-p300-ACE pathway. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
2 Furthermore, nicotine induced histone acetylase p300 into the nuclei of the BMSCs by acting on the alpha4beta2-nicotinic acetylcholine receptor (alpha4beta2-nAChR), leading to the increased histone 3 lysine 9 acetylation level of ACE and RAS activation. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
3 Taken together, the sustained activation of local bone RAS mediated prenatal nicotine-induced osteopenia in adult offspring via the alpha4beta2-nAChR-p300-ACE pathway.-Xiao, H., Wen, Y., Pan, Z., Shangguan, Y., Magdalou, J., Wang, H., Chen, L. Nicotine exposure during pregnancy programs osteopenia in male offspring rats via alpha4beta2-nAChR-p300-ACE pathway. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
4 Taken together, the sustained activation of local bone RAS mediated prenatal nicotine-induced osteopenia in adult offspring via the alpha4beta2-nAChR-p300-ACE pathway.-Xiao, H., Wen, Y., Pan, Z., Shangguan, Y., Magdalou, J., Wang, H., Chen, L. Nicotine exposure during pregnancy programs osteopenia in male offspring rats via alpha4beta2-nAChR-p300-ACE pathway. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus