Title : EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway.

Pub. Date : 2020 Jan

PMID : 31490284






1 Functional Relationships(s)
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1 Treatment with EX527 increased the number of apoptotic cells (Annexin V-fluorescein isothiocyanate/propidium iodide); pretreatment with the caspase inhibitor Z-VAD-FMK suppressed EX527-induced apoptosis, suggesting that EX527 induced caspase-dependent apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone annexin A5 Homo sapiens