Title : Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production.

Pub. Date : 2019 Nov

PMID : 31386885

1 Functional Relationships(s)
Compound Name
Protein Name
1 The apoptotic process was probably mediated via ROS overproduction and MAPK (ERK and JNK) activation as N-acetylcysteine, or specific inhibitors of these kinases prevented the XN-induced caspase-3 activity and, hence, apoptosis. Acetylcysteine caspase 3 Homo sapiens