Title : Astragaloside inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.

Pub. Date : 2019 Aug

PMID : 31293216






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. Dinoprostone interleukin 1 beta Homo sapiens
2 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. Dinoprostone interleukin 1 beta Homo sapiens