Pub. Date : 2019 Jul 5
PMID : 31277592
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PPARgamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3. | Pioglitazone | early growth response 1 | Mus musculus |
| 2 | Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-beta1, CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation. | Pioglitazone | early growth response 1 | Mus musculus |
| 3 | CONCLUSIONS: Oral administration of PPARgamma agonist pioglitazone significantly reduces TGF-beta1-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1. | Pioglitazone | early growth response 1 | Mus musculus |