Title : Sodium butyrate protects against high-fat diet-induced oxidative stress in rat liver by promoting expression of nuclear factor E2-related factor 2.

Pub. Date : 2019 Aug 28

PMID : 31204637






7 Functional Relationships(s)
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1 Sodium butyrate (NaB) has been shown to alleviate oxidative stress and insulin resistance, yet how Nrf2 is involved in the action of NaB remains unclear. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 Additionally, the insulin signalling pathway in the liver was activated by NaB, associated with significant activation of Nrf2, superoxide dismutase and glutathione. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
3 Furthermore, hepatic up-regulation of Nrf2 in NaB-treated rats was associated with reduced protein content of histone deacetylase 1 and increased histone H3 acetyl K9 (H3K9Ac) modification on the Nrf2 promoter. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
4 Furthermore, hepatic up-regulation of Nrf2 in NaB-treated rats was associated with reduced protein content of histone deacetylase 1 and increased histone H3 acetyl K9 (H3K9Ac) modification on the Nrf2 promoter. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
5 The actions of NaB were completely abolished when Nrf2 was knocked down in vitro. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
6 Taken together, NaB acts as a histone deacetylase inhibitor to up-regulate Nrf2 expression with enhanced H3K9Ac modification on its promoter. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
7 NaB-induced Nrf2 activation stimulates transcription of downstream antioxidant enzymes, thus contributing to the amelioration of high-fat diet-induced oxidative stress and insulin resistance. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus