Title : iPLA2 Activation Mediates Granular Exocytosis and Corrects Microbicidal Defects in ROS-Deficient and CGD Human Neutrophils.

Pub. Date : 2019 Jul

PMID : 31154555






1 Functional Relationships(s)
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1 PURPOSE: The ubiquitous calcium-independent phospholipase A2 enzyme (iPLA2) is inhibited by calmodulin binding and known to be responsible for phospholipid remodeling housekeeping functions including granule exocytosis-associated membrane fusion in normal human neutrophils. Phospholipids patatin like phospholipase domain containing 2 Homo sapiens