Pub. Date : 2019 Aug
PMID : 31077767
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Midostaurin induced G2/M arrest and inhibited CDK2, preventing the phosphorylation of SAMHD1 associated to inhibition of its dNTPase activity. | midostaurin | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 2 | In the presence of SAMHD1, midostaurin blocked HIV-1 DNA formation and viral replication. | midostaurin | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 3 | Our study describes a dual effect for midostaurin in HIV-1 infection, antiviral or proviral depending on SAMHD1 activation, and highlights a role for active SAMHD1 in regulating the activity of potential HIV-1 latency reversal agents. | midostaurin | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |