Title : Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells.

Pub. Date : 2019 Jul

PMID : 31068382






3 Functional Relationships(s)
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1 The goal of the present study was to test the hypothesis that beta 2AR production of cAMP is localized to specific subcellular compartments using fluorescence resonance energy transfer-based cAMP biosensors targeted to different microdomains in human ASM cells. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 The goal of the present study was to test the hypothesis that beta 2AR production of cAMP is localized to specific subcellular compartments using fluorescence resonance energy transfer-based cAMP biosensors targeted to different microdomains in human ASM cells. Cyclic AMP adrenoceptor beta 2 Homo sapiens
3 Furthermore, overexpression of AC6 somewhat paradoxically inhibited beta 2AR production of cAMP in lipid raft domains without affecting beta 2AR responses detected in other subcellular locations or cAMP responses to EP2 prostaglandin receptor activation, which were confined primarily to nonraft domains of the plasma membrane. Cyclic AMP adrenoceptor beta 2 Homo sapiens