Title : Aromatic boronic acids as probes of the catalytic site of human plasma lecithin-cholesterol acyltransferase.

Pub. Date : 1987 Apr 3

PMID : 3103690






1 Functional Relationships(s)
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1 We now confirm the involvement of serine and histidine in catalysing the phospholipase A2 action of lecithin-cholesterol acyltransferase by demonstrating the inhibition of this activity by phenylboronic acid (Ki = 1.23 mM) and m-aminophenylboronic acid (Ki = 2.32 mM), inhibitors of known serine/histidine hydrolases. 3-aminobenzeneboronic acid lecithin-cholesterol acyltransferase Homo sapiens