Title : In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione.

Pub. Date : 2019 Oct

PMID : 30993552






2 Functional Relationships(s)
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1 METHODS: Treosulfan (200 muM) was incubated at pH 7.2 and 37 C with 5 mM GSH in the presence or absence of human liver cytosol, the main store of glutathione S-transferase in the body. treosulfan glutathione S-transferase kappa 1 Homo sapiens
2 The result indicates that the clearance of treosulfan is independent of glutathione S-transferase activity, GSH stores, and co-administration of drugs utilizing the GSH metabolic pathway. treosulfan glutathione S-transferase kappa 1 Homo sapiens