Title : Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy.

Pub. Date : 2019 Apr 23

PMID : 30892297






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1 Owing to the glutathione (GSH)-responsive biodegradation behavior of the disulfide-doped organosilica gatekeeper, the DOX-loaded POMSNs exhibit only 20% cell viability towards SMMC-7721 tumor cells, and almost no toxicity towards L-02 cells at a DOX concentration of 50 mug mL-1 was measured, demonstrating their selective cytotoxicity in vitro. Doxorubicin L1 cell adhesion molecule Mus musculus