Title : N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia.

Pub. Date : 2019 Jul

PMID : 30734924






2 Functional Relationships(s)
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1 Experimental inactivation of MARS prevented the N-homocysteinylation of tau and MAP1, and the dissociation of tau and MAP1 from beta-tubulin and PSD95 in cultured neuroprogenitors. Nitrogen methionyl-tRNA synthetase 1 Homo sapiens
2 In conclusion, increased N-homocysteinylation of tau and MAP1 is a mechanism of brain ageing that depends on Hcy concentration and expression of MARS enzyme. Nitrogen methionyl-tRNA synthetase 1 Homo sapiens