Title : Alanine Scanning Effects on the Biochemical and Biophysical Properties of Intrinsically Disordered Proteins: A Case Study of the Histidine to Alanine Mutations in Amyloid-β42.

Pub. Date : 2019 Feb 25

PMID : 30694660






2 Functional Relationships(s)
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1 To this end, we studied the impact of widely used histidine to alanine mutations in amyloid-beta (Abeta). Histidine amyloid beta precursor protein Homo sapiens
2 We found that the secondary and tertiary contacts, salt bridge formations, and thermodynamic properties, as well as disorder propensities and aggregation predisposition of Abeta, are impacted by the single and triple point histidine to alanine mutations. Histidine amyloid beta precursor protein Homo sapiens