Title : An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.

Pub. Date : 2019 Mar 15

PMID : 30674535






3 Functional Relationships(s)
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1 An ARC-Regulated IL1beta/Cox-2/PGE2/beta-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Dinoprostone interleukin 1 beta Homo sapiens
2 Malignant cells have been reported to release IL1beta, which induces PGE2 synthesis in mesenchymal stromal cells (MSC), in turn activating beta-catenin signaling and inducing the cancer stem cell phenotype. Dinoprostone interleukin 1 beta Homo sapiens
3 Here, we report that AML-MSC cocultures greatly increase Cox-2 expression in MSC and PGE2 production in an ARC/IL1beta-dependent manner. Dinoprostone interleukin 1 beta Homo sapiens