Title : Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 Biological Axis.

Pub. Date : 2018

PMID : 30504726






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: MKP1 was downregulated in the presence of chronic high-glucose stress in vivo and in vitro. Glucose dual specificity phosphatase 1 Mus musculus
2 However, MKP1 overexpression improved the metabolic parameters, enhanced glucose control, sustained renal function, attenuated kidney oxidative stress, inhibited the renal inflammation response, alleviated HRMC apoptosis, and repressed tubulointerstitial fibrosis. Glucose dual specificity phosphatase 1 Mus musculus