Title : Effect of ketoconazole on the 11-hydroxylation step of adrenal steroidogenesis.

Pub. Date : 1987 Jun

PMID : 3035728






1 Functional Relationships(s)
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1 We conclude that 400 mg of ketoconazole can decrease cortisol synthesis apparently through a partial block of the 11-beta-hydroxylation step; the observed degree of inhibition may not be sufficient to stimulate the hypothalamic-pituitary-adrenal axis or to cause overt symptoms or signs of adrenal insufficiency; and this partial block of the 11-beta-hydroxylation step becomes more evident during a continuous infusion of ACTH, which can stimulate a normal response of cortisol. Ketoconazole proopiomelanocortin Homo sapiens