Title : Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAFV600E mutation.

Pub. Date : 2019 Apr

PMID : 30320916






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib. Vemurafenib interleukin 6 Homo sapiens
2 Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib. Vemurafenib interleukin 6 Homo sapiens
3 STAT3 activation was induced by adding IL-6 to the supernatant, and IL-6 increased STAT3 and BCL-2 expression and antagonized vemurafenib sensitivity in HT-29 cells. Vemurafenib interleukin 6 Homo sapiens