Title : Inhibition of PI3K signaling pathway enhances the chemosensitivity of APL cells to ATO: Proposing novel therapeutic potential for BKM120.

Pub. Date : 2018 Dec 15

PMID : 30316766

1 Functional Relationships(s)
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1 Moreover, we found that the positive regulatory role of the PI3K inhibition in augmenting the intracellular level of reactive oxygen species disturbed the balance between the death promoter and death repressor genes, which in turn amplified the caspase-3-dependent apoptotic activity of ATO in NB4. Arsenic Trioxide caspase 3 Homo sapiens