Title : Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.

Pub. Date : 2019 Mar

PMID : 30260034






5 Functional Relationships(s)
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1 Continuous exposure to the mixture of 0.15 muM nicotine and 2 muM cotinine retarded pterygium cell proliferation by 16.04% (P = 0.009) and hindered their migration by 11.93% ( P = 0.039), without affecting cell apoptosis. Nicotine latexin Homo sapiens
2 SNAIL and alpha-smooth muscle actin protein expression was significantly downregulated in pterygium cells treated with 0.15 muM nicotine-2 muM cotinine mixture by 1.33- ( P = 0.036) and 1.31-fold ( P = 0.001), respectively. Nicotine latexin Homo sapiens
3 SNAIL and alpha-smooth muscle actin protein expression was significantly downregulated in pterygium cells treated with 0.15 muM nicotine-2 muM cotinine mixture by 1.33- ( P = 0.036) and 1.31-fold ( P = 0.001), respectively. Nicotine latexin Homo sapiens
4 Besides, the 0.15 muM nicotine-2 muM cotinine mixture also reduced matrix metalloproteinase (MMP)-1 and MMP-9 expressions in pterygium cells by 1.56- ( P = 0.043) and 1.27-fold ( P = 0.012), respectively. Nicotine latexin Homo sapiens
5 Besides, the 0.15 muM nicotine-2 muM cotinine mixture also reduced matrix metalloproteinase (MMP)-1 and MMP-9 expressions in pterygium cells by 1.56- ( P = 0.043) and 1.27-fold ( P = 0.012), respectively. Nicotine latexin Homo sapiens