Title : 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.

Pub. Date : 2018 Sep 18

PMID : 30228306






3 Functional Relationships(s)
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1 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
2 15deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) is a natural activator of PPAR-gamma with analgesic, anti-inflammatory, and pro-resolution properties. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
3 Therefore, we demonstrated that 15d-PGJ2-loaded NC present analgesic and anti-inflammatory properties in a PPAR-gamma-dependent manner inhibiting IL-1beta release and NF-kappaB activation in GA. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus