Title : The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities.

Pub. Date : 2018 Nov 16

PMID : 30224358






1 Functional Relationships(s)
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1 We report that linkage of this HCF-1PRO-repeat, threonine-rich region to heterologous substrate sequences also potentiates robust serine glycosylation with the otherwise poor R p-alphaS-UDP-GlcNAc diastereomer phosphorothioate and UDP-5S-GlcNAc OGT co-substrates. Parathion O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens