Title : Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Pub. Date : 2018 Oct 1

PMID : 30145050

1 Functional Relationships(s)
Compound Name
Protein Name
1 WaterMap analysis of the crystal structures suggests that unfavorable water molecules are the likely reason for the difference in orientation of the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold to the hinge region among JAKs. Water Janus kinase 1 Homo sapiens