Title : The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear β-catenin/c-Myc axis in OSCC.

Pub. Date : 2018 Aug 24

PMID : 30143678






2 Functional Relationships(s)
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1 We also showed that niclosamide effectively inhibits activation of the Wnt/beta-catenin signaling pathway by targeting multiple components of this pathway, including downregulating the expression beta-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3beta (p-GSK3beta) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as well as reduced the formation of primary and secondary tumorspheres. Niclosamide dishevelled segment polarity protein 2 Homo sapiens
2 We also showed that niclosamide effectively inhibits activation of the Wnt/beta-catenin signaling pathway by targeting multiple components of this pathway, including downregulating the expression beta-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3beta (p-GSK3beta) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as well as reduced the formation of primary and secondary tumorspheres. Niclosamide dishevelled segment polarity protein 2 Homo sapiens