Title : Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells.

Pub. Date : 2018 Aug 3

PMID : 30075754






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The histone deacetylase-inhibitor (HDAC) sodium butyrate (NaB) and the methylation-inhibitor 5-azacytidine (5-AZA), as epigenetic modifiers, induced CEA-expression in HCT116 and WiDr cells. nab CEA cell adhesion molecule 3 Homo sapiens
2 The cytolytic function of anti-CEA-CAR NK-92MI cells was increased from 22.99 +- 2.04% of lysis background to 69.20 +- 11.92% after NaB treatment, and 69.70 +- 9.93% after 5-AZA treatment, at a 10:1 E/T ratio in HCT116 cells. nab CEA cell adhesion molecule 3 Homo sapiens