Title : Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension.

Pub. Date : 2018 Jul 23

PMID : 30038227






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 PGE2 and PGF2alpha were topically applied to induce transient OH in Wild-type (WT) and FP-, EP1-, EP2-, and EP3-deficient (knockout [KO]) mice. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 PGE2 and PGF2alpha induced significant OH in the WT, FPKO, and EP1-3KO mice compared to the control 30 min after instillation, and the increase in IOP at 30 or 60 min after instillation in FPKO mice was significantly higher than that in the WT mice. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
3 Transient OH was induced by PGE2 and PGF2alpha in WT, FPKO, and EP1-3KO mice, which was enhanced in FPKO mice. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus