Title : Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats.

Pub. Date : 2018 Oct 15

PMID : 30036686






2 Functional Relationships(s)
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1 In vitro, nicotine (0.1-10 muM) reduced the expression of LXRalpha, LXRbeta, SR-B1, ABCA1 and ABCG1 in a concentration dependent manner, which could be annulled by nAChR antagonist and LXR agonist. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
2 Taken together, nicotine could inhibit the expression of SR-B1, ABCA1 and ABCG1 via nAChR and LXR alpha/beta in female placentas, finally leading to reduced blood cholesterol levels in fetal rats. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus