Title : 18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK-TRAF6 Interactions and NF-κB and MAPK Signaling Pathways.

Pub. Date : 2018

PMID : 29973878






5 Functional Relationships(s)
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1 18beta-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK-TRAF6 Interactions and NF-kappaB and MAPK Signaling Pathways. 18alpha-glycyrrhetinic acid tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
2 Here, we for the first time explored the effects of 18beta-glycyrrhetinic acid (18beta-GA), a pentacyclic triterpenoid found in the Glycyrrhiza glabra L roots, on RANKL-induced osteoclastogenesis, osteoclast functions and signaling pathways in vitro and in vivo. 18alpha-glycyrrhetinic acid tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
3 Here, we for the first time explored the effects of 18beta-glycyrrhetinic acid (18beta-GA), a pentacyclic triterpenoid found in the Glycyrrhiza glabra L roots, on RANKL-induced osteoclastogenesis, osteoclast functions and signaling pathways in vitro and in vivo. 18alpha-glycyrrhetinic acid tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
4 For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB. 18alpha-glycyrrhetinic acid tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
5 Overall, our results demonstrated that 18beta-GA inhibited RANKL-induced osteoclastogenesis by inhibiting RANK expression in preosteoclasts and blocking the binding of RANK and TRAF6 which lead to the inhibition of NF-kappaB and MAPK signaling pathways. 18alpha-glycyrrhetinic acid tumor necrosis factor (ligand) superfamily, member 11 Mus musculus