Title : Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183.

Pub. Date : 2018 Jun 26

PMID : 29949760






1 Functional Relationships(s)
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1 Here, we show that GPR183, a chemotactic receptor expressed on murine and human ILC3s, regulates ILC3 migration toward its ligand 7alpha,25-dihydroxycholesterol (7alpha,25-OHC) in vitro, and GPR183 deficiency in vivo leads to a disorganized distribution of ILC3s in mesenteric lymph nodes and decreased ILC3 accumulation in the intestine. 25-hydroxycholesterol G protein-coupled receptor 183 Mus musculus