Title : 18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.

Pub. Date : 2018 Jun 19

PMID : 29921924






3 Functional Relationships(s)
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1 We compared the roles of the ATF4/CHOP and IRE1alpha/XBP1s UPR pathways, which were both induced by GA. 18alpha-glycyrrhetinic acid endoplasmic reticulum to nucleus signaling 1 Homo sapiens
2 In contrast, the IRE1alpha/XBP1s cascade protected HCC cells from apoptosis in vitro and in vivo induced by GA. 18alpha-glycyrrhetinic acid endoplasmic reticulum to nucleus signaling 1 Homo sapiens
3 We concluded that pharmacological inhibition of autophagy or IRE1alpha may be of benefit to enhance the antitumor activity of GA. 18alpha-glycyrrhetinic acid endoplasmic reticulum to nucleus signaling 1 Homo sapiens