Title : XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation.

Pub. Date : 2018 Jun 18

PMID : 29910466






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 We could demonstrate that interaction between XKR5 and KIT/D816V leads to phosphorylation of XKR5 at Tyr 369, Tyr487, and Tyr 543. Tyrosine XK related 5 Homo sapiens
2 We could demonstrate that interaction between XKR5 and KIT/D816V leads to phosphorylation of XKR5 at Tyr 369, Tyr487, and Tyr 543. Tyrosine XK related 5 Homo sapiens
3 We could demonstrate that interaction between XKR5 and KIT/D816V leads to phosphorylation of XKR5 at Tyr 369, Tyr487, and Tyr 543. Tyrosine XK related 5 Homo sapiens
4 We could demonstrate that interaction between XKR5 and KIT/D816V leads to phosphorylation of XKR5 at Tyr 369, Tyr487, and Tyr 543. Tyrosine XK related 5 Homo sapiens
5 Tyrosine phosphorylated XKR5 acts as a negative regulator of KIT signaling, which leads to downregulation of phosphorylation of ERK, AKT, and p38. Tyrosine XK related 5 Homo sapiens