Title : A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo.

Pub. Date : 2018 Aug

PMID : 29870712






1 Functional Relationships(s)
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1 In addition, DHHL suppressed IL-4-induced STAT-6 and JAK-1 tyrosine phosphorylation, suggesting that this compound inhibited M2 polarization by suppressing the JAK-STAT signaling pathway. Tyrosine Janus kinase 1 Homo sapiens