Title : src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.

Pub. Date : 1985 May 10

PMID : 2985615

3 Functional Relationships(s)
Compound Name
Protein Name
1 When a partially purified insulin receptor preparation immobilized on insulin-agarose is incubated with [gamma-32P]ATP, Mn2+, and Mg2+ ions, the receptor beta subunit becomes 32P-labeled. Phosphorus-32 insulin receptor Homo sapiens
2 The 32P-labeling of the insulin receptor beta subunit is increased by 2-3-fold when src kinase is included in the phosphorylation reaction. Phosphorus-32 insulin receptor Homo sapiens
3 The Mr = 93,000 receptor beta subunit and the Mr = 125,000 32P-labeled bands are absent when an insulin receptor-deficient sample, prepared by the inclusion of excess free insulin to inhibit the adsorption of the receptor to the insulin-agarose, is phosphorylated in the presence of the src kinase. Phosphorus-32 insulin receptor Homo sapiens