Title : Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

Pub. Date : 2018

PMID : 29813086






2 Functional Relationships(s)
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1 qPCR analyses of 2-AG-stimulated macrophages showed an enhanced transcription of the chemokine CCL5 (1.59 +- 0.23 -fold; n = 5-6; p = 0.0589) and its corresponding receptors CCR1 (2.04 +- 0.46 -fold; n = 10-11; p = 0.0472) and CCR5 (2.45 +- 0.62 -fold; n = 5-6; p = 0.0554). glyceryl 2-arachidonate chemokine (C-C motif) ligand 5 Mus musculus
2 Our data suggest that 2-AG promotes macrophage migration, possibly by the CCL5-CCR5/CCR1 axis, and thereby contributes to vascular inflammation. glyceryl 2-arachidonate chemokine (C-C motif) ligand 5 Mus musculus