Title : Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctions.

Pub. Date : 2018 Aug 1

PMID : 29782988






1 Functional Relationships(s)
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1 In addition, cholesterol crystals induced tyrosine phosphorylation of VE-cadherin and alpha-catenin, disrupting endothelial AJ and its barrier function and these effects required xanthine oxidase-mediated H2O2 production, SHP2 inactivation and Frk activation. Tyrosine xanthine dehydrogenase Mus musculus