Pub. Date : 2018 Apr 1
PMID : 29739921
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bioinformatics analyses identified SRC kinase signaling inhibitor 1 (SRCIN1) as a potential target of miR-181a. | mir-181a | SRC kinase signaling inhibitor 1 | Homo sapiens |
| 2 | Bioinformatics analyses identified SRC kinase signaling inhibitor 1 (SRCIN1) as a potential target of miR-181a. | mir-181a | SRC kinase signaling inhibitor 1 | Homo sapiens |
| 3 | In addition, the biological effects of SRCIN1 inhibition by miR-181a were examined in vitro by quantitative RT-PCR, western blotting and enzyme-linked immunosorbent assay and in vivo by Matrigel plug angiogenesis assays and immunohistochemical staining. | mir-181a | SRC kinase signaling inhibitor 1 | Homo sapiens |
| 4 | In clinical samples, Fluorescence in situ hybridization and immunofluorescence were performed to detect the relation between miR-181a and SRCIN1. | mir-181a | SRC kinase signaling inhibitor 1 | Homo sapiens |
| 5 | In conclusion, miR-181a inhibited SRCIN1, which caused SRC to transform from an inactive status to an active conformation and to trigger vascular endothelial growth factor secretion, leading to increased angiogenesis. | mir-181a | SRC kinase signaling inhibitor 1 | Homo sapiens |