Title : A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Pub. Date : 2018 May 1

PMID : 29719225






3 Functional Relationships(s)
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1 A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. NAD CD38 antigen Mus musculus
2 We recently demonstrated that the NADase CD38 has a central role in age-related NAD+ decline. NAD CD38 antigen Mus musculus
3 Here we show that a highly potent and specific thiazoloquin(az)olin(on)e CD38 inhibitor, 78c, reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging. NAD CD38 antigen Mus musculus