Title : Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis.

Pub. Date : 2018 Mar 22

PMID : 29565268






3 Functional Relationships(s)
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1 Remarkably, when A549 cells were subjected to hinokitiol (1-5 microM), there was an increase in the activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) from the reduction in cells. beta-thujaplicin superoxide dismutase 1 Homo sapiens
2 Remarkably, when A549 cells were subjected to hinokitiol (1-5 microM), there was an increase in the activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) from the reduction in cells. beta-thujaplicin superoxide dismutase 1 Homo sapiens
3 These observations indicate that hinokitiol inhibited the migration of lung cancer A549 cells through several mechanisms, including the activation of caspases-9 and -3, induction of p53/Bax and antioxidant CAT and SOD, and reduction of MMP-2 and -9 activities. beta-thujaplicin superoxide dismutase 1 Homo sapiens