Pub. Date : 2018 Feb 13
PMID : 29535810
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway. | Reactive Oxygen Species | TNF receptor superfamily member 10b | Homo sapiens |
| 2 | Furthermore, silibinin increased the production of reactive oxygen species (ROS), which led to the induction of TRAIL-mediated apoptosis through DR5 upregulation. | Reactive Oxygen Species | TNF receptor superfamily member 10b | Homo sapiens |
| 3 | Furthermore, silibinin increased the production of reactive oxygen species (ROS), which led to the induction of TRAIL-mediated apoptosis through DR5 upregulation. | Reactive Oxygen Species | TNF receptor superfamily member 10b | Homo sapiens |
| 4 | Accordingly, we showed that ROS/ER stress-induced CaMKII activated Sp1, which is an important transcription factor for DR5 expression. | Reactive Oxygen Species | TNF receptor superfamily member 10b | Homo sapiens |
| 5 | Our results showed that silibinin enhanced TRAIL-induced apoptosis by upregulating DR5 expression through the ROS-ER stress-CaMKII-Sp1 axis. | Reactive Oxygen Species | TNF receptor superfamily member 10b | Homo sapiens |