Title : Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.

Pub. Date : 2018 Mar 2

PMID : 29500363






2 Functional Relationships(s)
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1 We find that by improving insulin sensitivity at the level of the insulin receptor (IR), either by IR over-expression or by knocking down the negative regulator of IR activity, protein tyrosine-phosphatase 1B (PTP1B), podocytes are protected from ER stress caused by fatty acids or diabetic media containing high glucose, high insulin and inflammatory cytokines TNFalpha and IL-6. Glucose insulin receptor Homo sapiens
2 We find that by improving insulin sensitivity at the level of the insulin receptor (IR), either by IR over-expression or by knocking down the negative regulator of IR activity, protein tyrosine-phosphatase 1B (PTP1B), podocytes are protected from ER stress caused by fatty acids or diabetic media containing high glucose, high insulin and inflammatory cytokines TNFalpha and IL-6. Glucose insulin receptor Homo sapiens